A complete, cloud-native clinical genomics platform — managing the full genomic testing lifecycle with HIPAA-compliant architecture, ACMG variant classification workflow software, HL7 FHIR EHR integration, and automated clinical report generation.
Six integrated modules. One governed system. Every capability designed for the clinical production environment — not adapted from a research tool.
Clinician-facing order entry with pre-authorization, payer eligibility checks, and requisition generation. Integrated with Epic and Cerner via HL7 FHIR — no duplicate data entry.
Barcode-driven sample tracking software for clinical labs — automated routing, real-time status visibility, TAT monitoring, and chain-of-custody logging from receipt to sequencer.
Configurable bioinformatics pipeline execution for WES, WGS, RNA-Seq, and targeted panels — auto-scaling on AWS, GCP, or Azure with sequencer-to-pipeline automation and cost-per-sample tracking.
ACMG variant classification workflow software with structured evidence capture, VUS management, multi-analyst review, somatic tiering per AMP guidelines, and knowledge base integration — ClinVar, ClinGen, OMIM.
Automated clinical report generation from classified variants to structured PDF and FHIR R4 DiagnosticReport — with amendment workflows, approval routing, and direct delivery to provider portals.
Clinician and patient-facing portals with EHR genomics integration for Epic and Cerner result delivery, genetic counseling scheduling, cascade screening workflows, and consent management.
The platform runs on HIPAA-compliant cloud genomics infrastructure with end-to-end encryption, VPC isolation, immutable audit trails, and a 99.9% uptime SLA, engineered for deployment on AWS, GCP, or Azure. Every integration follows HL7 FHIR genomics integration standards, and every pipeline run is Kubernetes-orchestrated for auto-scaling and fault tolerance.
Tell us your assay types, your current system stack, and your compliance requirements. We scope every Clinical Genomics Platform build to your exact operational context.
How is NonStop’s Clinical Genomics Platform different from a standard LIMS?
A LIMS tracks samples and test status. NonStop’s Clinical Genomics Platform connects that to NGS pipeline development services, ACMG variant classification workflow software, automated clinical report generation, HL7 FHIR EHR delivery, and patient and provider portals — in one governed, HIPAA-compliant system. It is the difference between a system of record and a system of operation. Labs using the platform replace 4–6 standalone tools with a single integrated clinical genomics platform, reducing handoff errors, compressing TAT, and entering every accreditation audit with a complete, unbroken digital audit trail.
Can the platform be configured for both germline and somatic genomics workflows?
Yes. The platform supports configurable bioinformatics pipeline execution for germline workflows — WES and WGS with GATK HaplotypeCaller and DeepVariant — and somatic workflows, including tumour-normal paired analysis, liquid biopsy panels for low-VAF detection, and oncology-specific tertiary analysis with AMP/ASCO/CAP somatic variant tiering. ACMG variant classification and somatic tiering run as separate configurable modules within the same interpretation workflow layer, so labs running both test types operate through a single unified platform rather than maintaining parallel systems. Pharmacogenomics panel workflows are also supported, including CPIC-compliant star-allele determination and pharmacogenomics CDS EHR integration for point-of-care prescribing alerts.
