Question 1

How does pharmacogenomics CDS EHR integration work in practice with Epic?

Accepted Answer

PGx CDS integration with Epic uses FHIR R4 resources and CDS Hooks for real-time prescribing support. Pharmacogenomic variants and metabolizer phenotypes are stored as FHIR Observation resources. When a clinician places a medication order, CDS Hooks evaluate the patient's PGx profile against CPIC and PharmGKB guidance and display prescribing recommendations directly within the Epic workflow.

Question 2

Which pharmacogenes and drugs does the platform cover?

Accepted Answer

The platform supports CPIC Level A gene-drug pairs including CYP2D6, CYP2C19, CYP2C9, DPYD, SLCO1B1, TPMT, NUDT15 and HLA-B. It also incorporates PharmGKB evidence and supports more than 150 drug-gene interactions.